Molecular Bioelectrostatics & Drug Delivery Laboratory
Located at Northeastern University’s Interdisciplinary Science and Engineering Complex (ISEC), the Bajpayee Lab works at the intersection of biomaterials design, nanomedicine and translational research. We utilize the body’s internal electric fields to design electrically charged biomaterials using proteins, peptides and cellular materials like exosomes, for targeting difficult to reach tissues for applications in drug delivery and diagnostic imaging.
Negatively charged tissues such as cartilage, meniscus, intervertebral disc, eye, and mucosal membrane, that also tend to be dense and avascular, are ubiquitous in the human body but remain outstanding challenges for targeted drug delivery. Their degeneration is associated with several common diseases that remain untreatable due to a lack of delivery systems that can enable drugs to penetrate the negatively charged matrix and reach their cellular targets. The high negative fixed charge density, however, can be converted from being a challenge to an opportunity by engineering therapeutics at the molecular level to add optimally positively charged domains such that electrostatic interactions can enhance their transport, uptake and retention rather than hindering them. Our lab engineers targeted bioelectrical therapeutics for treatment of diseases affecting such intrinsically charged tissues. We strive to combine basic science with translational research to develop biomedical technologies for unmet clinical needs.
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Our Lab News
Excited to share Tim and Co-Authors’ recent work published in Osteoarthritis & Cartilage evaluating cationic peptide carriers for drug delivery in a rabbit model of post-traumatic osteoarthritis
In collaboration with Dr. Ryan Porter at UAMS, Timothy Boyer and Co-Authors evaluated the kinetics, stability, and immunogenicity of Cationic Peptide Carriers (CPCs) after a single intra-articular injection using a rabbit knee injury model. Our key findings: CPCs...
Prof. Bajpayee was honored at Northeastern 15th Academic Honors Convocation
Prof. Bajpayee's PECASE award was celebrated at Wednesday's event (4/16) along with several other students and faculty achievers across 13 global campuses of Northeastern University. Congrats! You can read the news [HERE]!
Recap from 2025 SFB Annual Meeting!
It was a great opportunity for us to present our works on this year Society for Biomaterials (SFB) annual meeting in Chicago. Andrew Selvadoss presented a poster on cartilage-targeting hybdrid exosomes for OA treatment on Friday (4/11) and Bill Hakim presented a talk...