The Bajpayee Lab @ Northeastern

Molecular Bioelectrostatics & Drug Delivery

Publications

  • C. Zhang, T.V. Pathrikar, H.M. Baby, J. Li, H. Zhang, A. Selvadoss, A. Ovchinnikova, A. Ionescu, S. Chubinskaya, R.E. Miller, A.G. Bajpayee, Charge-Reversed Exosomes for Targeted Gene Delivery to Cartilage for Osteoarthritis Treatment. Small Methods, 2024 [LINK]
  • C. Zhang, H. Zhang, H.A. Millan-Cotto, T. L. Boyer, M.R. Warren, C.M. Wang, J. Luchan, P.K. Dhal, R.L. Carrier, A.G. Bajpayee, Milk exosomes anchored with hydrophilic and zwitterionic motifs enhance mucus permeability for applications in oral gene delivery. Biomaterials Science, 2023 [LINK] 
  • C. Zhang, A. Vedadghavami, T. He, J. Charles, A.G. Bajpayee, Cationic Carrier Mediated Delivery of Anionic Contrast Agents in Low Doses Enable Enhanced Computed Tomography Imaging of Cartilage for Early Osteoarthritis Diagnosis. ACS Nano, 2023 [LINK] 
  • S. Mehta, T.L. Boyer, S. Akhtar, T. He, C. Zhang, A. Vedadghavami, A.G. Bajpayee, Sustained intra-cartilage delivery of interleukin-1 receptor antagonist using cationic peptide and protein-based carriers. Osteoarthritis & Cartilage, 2023 [LINK] 
  • P. K. R. Valluru, A. Su, S. Mehta, A.G. Bajpayee, S. J. Shefelbine, Spatial and Temporal Mapping of Articular Cartilage Poro-Viscoelastic Material Properties Using Indentation. ASME J Biomech Eng, 2023 [LINK] 
  • T. He, C. Zhang, T. Colombani, S.A. Bencherif, R.M. Porter, A.G. Bajpayee, Intra-articular kinetics of a cartilage targeting cationic PEGylated protein for applications in drug delivery. Osteoarthritis and Cartilage, 2022 [LINK] 
  • A. Vedadghavami, T. He, C. Zhang, S.M. Amiji, B. Hakim, A.G. Bajpayee, Charge-based drug delivery to cartilage: Hydrophobic and not electrostatic interactions are the dominant cause of competitive binding of cationic carriers in synovial fluid. Acta Biomaterialia, 2022 [LINK] 
  • A. Vedadghavami, B. Hakim, T. He, A.G. Bajpayee, Cationic peptide carriers enable long-term delivery of insulin-like growth factor-1 to suppress osteoarthritis-induced matrix degradation. Arthritis Research & Therapy, 2022 [LINK] 
  • M.R. Warren, A. Vedadghavami, S. Bhagavatula, A.G. Bajpayee, Effects of polycationic drug carriers on the electromechanical and swelling properties of cartilage. Biophysical Journal, 2022 [LINK] 
  • S. B. Tahar, J. Garnier, K. Eller, N. DiMauro, J. Piet, S. Mehta, A. G. Bajpayee, S. J. Shefelbine, Adolescent obesity incurs adult skeletal deficits in murine induced obesity model. Journal of Orthopaedic Research, 2022 [LINK] 
  • T. He, I. Shaw, A. Vedadghavami, A.G. Bajpayee, Single-Dose Intra-Cartilage Delivery of Kartogenin Using a Cationic Multi-Arm Avidin Nanocarrier Suppresses Cytokine-Induced Osteoarthritis-Related Catabolism. Cartilage, 2022 [LINK] 
  • M.R. Warren, A.G. Bajpayee, Modeling Electrostatic Charge Shielding Induced by Cationic Drug Carriers in Articular Cartilage Using Donnan Osmotic Theory, Bioelectricity, 2021 [LINK] 
  • S. Mehta, C.C. Young, M.R. Warren, S. Akhtar, S.J. Shefelbine, J.D. Crane, A.G. Bajpayee, Resveratrol and Curcumin attenuate ex vivo sugar-induced cartilage glycation, stiffening, senescence and degradation, Cartilage, 2021 [LINK] 
  • M.R. Warren, C. Zhang, A. Vedadghavami, K. Bokvist, P.K. Dhal, A.G. Bajpayee, Milk exosomes with enhanced mucus penetrability for oral delivery of siRNA, Biomaterials Science, 2021 [LINK]
  • S. Mehta, T. He, A.G. Bajpayee, Recent Advances in Targeted Drug Delivery for Treatment of Osteoarthritis, Current Opinion in Rheumatology, 2020 [LINK]
  • T. He, B. Li, T. Colombani, K. Joshi-Navare, S. Mehta, J. Kisiday, S. Bencherif, A.G. Bajpayee, Hyaluronic acid -based shape-memory cryogel scaffolds for focal cartilage defect repair, Tissue Engineering Part A, 2020 [LINK]
  • A. Vedadghavami, S. Mehta, A.G. Bajpayee, Characterization of Intra-Cartilage Transport Properties of Cationic Peptide Carriers, Journal of Visualized Experiments, 2020  [LINK]
  • E.K. Wagner, A. Vedadghavami, T.D. Jacobsen, S.A. Goel, N.O. Chahine, A.G. Bajpayee, Avidin grafted dextran nanostructure enables a month-long intra-discal retention, Scientific Reports, 2020 [LINK]
  • A. Vedadghavami, C. Zhang, A.G. Bajpayee, Overcoming negatively charged tissue barriers: Drug delivery using cationic peptides and proteins, Nano Today, 2020 [LINK]
  • C.C. Young, A. Vedadghavami, A.G. Bajpayee, Bioelectricity for Drug Delivery: The Promise of Cationic Therapeutics, Bioelectricity, 2020 [LINK]
  • C. Zhang, T. He, A. Vedadghavami, A.G. Bajpayee, Avidin-biotin technology to synthesize multi-arm nano-construct for drug delivery, MethodsX, 2020 [LINK]
  • T. He, C. Zhang, A. Vedadghavami, S. Mehta, H.A. Clark, R.M. Porter, A.G. Bajpayee, Multi-arm Avidin nano-construct for intra-cartilage delivery of small molecule drugs, Journal of Controlled Release, 2019   [LINK]
  • S. Mehta, S. Akhtar, R.M. Porter, P. Onnerfjord, A.G. Bajpayee, Interleukin-1 receptor antagonist (IL-1Ra) is more effective in suppressing cytokine induced catabolism in cartilage-synovium co-culture than cartilage monoculture, Arthritis Research Therapy, 2019   [LINK]
  • A. Vedadghavami, E.K. Wagner, S. Mehta, T. He, C. Zhang, A.G. Bajpayee, Cartilage penetrating cationic peptide carriers for applications in drug delivery to avascular negatively charged tissues, Acta Biomaterialia, 2019   [LINK]
  • A.R. Kirtane, T Hua, A Hayward,  A.G. Bajpayee et al, A once-a-month oral contraceptive, Science Translation Medicine, 2019 [LINK]
  • Hayward, T. Bensel, H. Mazdiyasni, J. Rogner, A. Kirtane, Y. Lee, T. Hua, A.G. Bajpayee, J. Collins, S. McDonnell, C. Cleveland, A. Lopes, A. Wahane, R. Langer, G. Traverso, Scalable Gastric Resident Systems for Veterinary Applications, Scientific Reports, 2018    [LINK]
  • B. Pouran, V Arbabi, A.G. Bajpayee, J. V. Tiel, J. Toyras, J.S. Jurvelin et al, Multi-scale imaging techniques to investigate solute transport across articular cartilage, Journal of Biomechanics, 2018    [LINK]
  • A.G. Bajpayee, R.E. De La Vega, M Scheu, N.H. Varady, I. A. Yannatos, L.A. Brown et al, Sustained intra-cartilage delivery of low dose dexamethasone using a cationic carrier for treatment of post traumatic osteoarthritis, European Cell & Materials, 2017    [LINK]
  • A.G. Bajpayee, A.J. Grodzinsky, Cartilage Targeting Drug Delivery: Can Electrostatic Interactions Help?, Nature Rheumatology Reviews, 2017    [LINK]
  • A.G. Bajpayee, M.A. Quadir, P.T. Hammond, A.J. Grodzinsky, Charge Based Intra-cartilage Delivery of Single Dose Dexamethasone Using Avidin Nano-carriers Suppresses Cytokine-induced Catabolism Long Term, Osteoarthritis & Cartilage, 24(1), 2016, 71-81    [LINK]
  • Editorial highlight by CH Evans, Drug Delivery to Chondrocytes, Osteoarthritis & Cartilage, 24(1), 2016, 1-2  [LINK]
  • A.G. Bajpayee, A.M. Sheu, A.J. Grodzinsky, R.M. Porter, A Rabbit Model Demonstrates the Influence of Cartilage Thickness on Intra-articular Drug Delivery and Retention within Cartilage, Journal of Orthopaedic Research, 33(5), 2015, 660-667    [LINK]
  • A.G. Bajpayee, A.M. Sheu, A.J. Grodzinsky, R.M. Porter, Electrostatic Interactions Enable Rapid Penetration, Enhanced Uptake and Retention of Intra-articular Injected Avidin in Rat Knee Joints, Journal of Orthopaedic Research, 32(8), 2014, 1044-1051    [LINK]
  • A.G. Bajpayee, C.R. Wong, M.G. Bawendi, E.H. Frank, A.J. Grodzinsky, Avidin as a Model for Charge Driven Transport into Cartilage and Drug Delivery for Treating Early Stage PTOA, Biomaterials, 35(1), 2014, 538-549    [LINK]

Patents

  • AG Bajpayee, AJ Grodzinsky, CR Wong, RN Karnik, MG Bawendi, Surface Binding of Nanoparticles- Based Drug Delivery to Tissue, US Patent # 9289506, Issued 2016
  • AG Bajpayee, AJ Grodzinsky, CR Wong, RN Karnik, MG Bawendi, Surface Binding of Nanoparticles- Based Drug Delivery to Tissue, US Patent # 10226427, Issued 2019
  • European and Japanese applications for above cases have been filed (EP2941243A1, JP2016511747A), Filed 2014
  • AG Bajpayee, C Zhang, A Vedadghavami, T He, Cationic nanostructures for intra-cartilage delivery of therapeutics and contrast agents, US Patent # 20210154307A1, Filed 2019.
  • AG Bajpayee, C Zhang, MR Warren, Cationic peptide/protein modified exosomes for tissue targeting for applications in drug delivery, US Patent # 63/399317, Filed 2022.

Book Chapters

  • C Zhang, AG Bajpayee, Charge driven contrast enhanced computed tomography for imaging of negatively charged tissues, Invited Book Chapter, Methods in Molecular Biology, 3rd Edition, Humana Press (Springer Science) 2022; 2393: 797-812.
  • T He, C Zhang, AG Bajpayee, Charge-based multi-arm avidin nano-construct as a platform technology for applications in drug delivery, Invited Book Chapter, Methods in Molecular Biology, 3rd Edition, Humana Press (Springer Science) 2022; 2394: 537-553.