Our Lab News
Read our new ACS Nano publication about CT imaging for Cartilage! 📄
Our work demonstrates development of optimally charged cationic contrast agents for targeting negatively charged cartilage, enabling it for CT imaging. These contrast agents work at very low doses due to their charge based high intra-cartilage uptake. Great Work...
Congrats to Tanvi and Tim on their Prize Posters at the College of Engineering Expo! 🏆
Tanvi and Tim won the prize for poster categories at the College of Engineering Expo. Congrats!
Read our new work in Osteoarthritis and Cartilage! 📄
Our recently published article explores the use of combining IL-1Ra with cationic drug delivery carriers for post-traumatic osteoarthritis. The work demonstrates that electrically charged IL-1Ra is more effective than neutral IL-1Ra in repairing cartilage. It...
We had a great time at the 2023 Orthopaedic Research Society Annual Meeting in Dallas, TX! 🌆
We presented some of our works at 2023 Orthopaedic Research Society Annual Meeting in Dallas, TX: Bioelectricity in Medicine Drug Delivery using Charged Biomaterials - Ambika (Spotlight Talk) Cationic Peptide Modified Exosomes for Cartilage Targeting for Applications...
Our recent work about intra-articular kinetics of multi-arm Avidin is now published in Osteoarthritis and Cartilage📄
Congrats to Tengfei for his last Ph.D. work in our lab published in Osteoarthritis and Cartilage: Intra-articular kinetics of a cartilage targeting cationic PEGylated protein for applications in drug delivery. This paper is now available online [HERE]
Happy to announce that the Biophysical Journal recently published a new and notable editorial highlighting our work on effects of cationic carriers on cartilage mechanics!📄
Our work previously on the effect of polycationic peptide carriers on cartilage electromechanical properties was highlighted in the "New and Notable" section of Biophysical Journal. Read it [HERE]
Our latest publication in Acta Biomaterialia developing cationic peptide carriers for cartilage targeting📄
This is our latest work on cationic peptide carriers (CPC) for cartilage targeting in drug delivery for osteoarthritis. We found significant competing interactions between CPC with synovial fluid constituents before uptake in cartilage and investigated the in vivo...
Application of cationic peptides in drug delivery published in Arthritis Research Therapy📄
Congrats to Armin, Bill, and Tengfei for their recent publication in Arthritis Research Therapy! Armin led this work in demonstrating that cationic peptide-conjugated IGF is more effective in suppressing OA-associated catabolism than unmodified IGF. This is the first...
Effects of polycationic drug carriers on the electromechanical and swelling properties of cartilage published in Biophysical Journal📄
Congratulations to Matt, Armin, and Sanjana on this paper published by Biophysical Journal! We demonstrated that charge-based drug delivery using polycationic peptide affects the electromechanical properties of cartilage. You can read the paper [HERE]