Our Lab News
We loved sharing new research at the Society for Biomaterials in San Diego! ๐
We presented our works at Society for Biomaterials (SFB) 2023 Annual Meeting: Bill: Spatial Configuration of Charge Modulates Transport of Cationic Peptides in Cartilage Matrix (Podium) Tanvi: Cationic Exosomes Anchored with Receptor Antagonist of IL-1 for Cartilage...
Our Research was Highlighted by Northeastern College of Engineering! ๐จ
Our work on cationic contrast agent application for the diagnosis of early-stage osteoarthritis was highlighted by Northeastern University College of Engineering. Read [HERE]
Read our new ACS Nano publication about CT imaging for Cartilage! ๐
Our work demonstrates development of optimally charged cationic contrast agents for targeting negatively charged cartilage, enabling it for CT imaging. These contrast agents work at very low doses due to their charge based high intra-cartilage uptake. Great Work...
Congrats to Tanvi and Tim on their Prize Posters at the College of Engineering Expo! ๐
Tanvi and Tim won the prize for poster categories at the College of Engineering Expo. Congrats!
Read our new work in Osteoarthritis and Cartilage! ๐
Our recently published article explores the use of combining IL-1Ra with cationic drug delivery carriers for post-traumatic osteoarthritis. The work demonstrates that electrically charged IL-1Ra is more effective than neutral IL-1Ra in repairing cartilage. It...
We had a great time at the 2023 Orthopaedic Research Society Annual Meeting in Dallas, TX! ๐
We presented some of our works at 2023 Orthopaedic Research Society Annual Meeting in Dallas, TX: Bioelectricity in Medicine Drug Delivery using Charged Biomaterials - Ambika (Spotlight Talk) Cationic Peptide Modified Exosomes for Cartilage Targeting for Applications...
Our recent work about intra-articular kinetics of multi-arm Avidin is now published in Osteoarthritis and Cartilage๐
Congrats to Tengfei for his last Ph.D. work in our lab published in Osteoarthritis and Cartilage: Intra-articular kinetics of a cartilage targeting cationic PEGylated protein for applications in drug delivery. This paper is now available online [HERE]
Happy to announce that the Biophysical Journal recently published a new and notable editorial highlighting our work on effects of cationic carriers on cartilage mechanics!๐
Our work previously on the effect of polycationic peptide carriers on cartilage electromechanical properties was highlighted in the "New and Notable" section of Biophysical Journal. Read it [HERE]
Our latest publication in Acta Biomaterialia developing cationic peptide carriers for cartilage targeting๐
This is our latest work on cationic peptide carriers (CPC) for cartilage targeting in drug delivery for osteoarthritis. We found significant competing interactions between CPC with synovial fluid constituents before uptake in cartilage and investigated the in vivo...