Molecular Bioelectrostatics & Drug Delivery Laboratory
Located at Northeastern Universityโs Interdisciplinary Science and Engineering Complex (ISEC), the Bajpayee Lab works at the intersection of biomaterials design, nanomedicine and translational research. We utilize the bodyโs internal electric fields to design electrically charged biomaterials using proteins, peptides and cellular materials like exosomes, for targeting difficult to reach tissues for applications in drug delivery and diagnostic imaging.
Negatively charged tissues such as cartilage, meniscus, intervertebral disc, eye, and mucosal membrane, that also tend to be dense and avascular, are ubiquitous in the human body but remain outstanding challenges for targeted drug delivery. Their degeneration is associated with several common diseases that remain untreatable due to a lack of delivery systems that can enable drugs to penetrate the negatively charged matrix and reach their cellular targets. The high negative fixed charge density, however, can be converted from being a challenge to an opportunity by engineering therapeutics at the molecular level to add optimally positively charged domains such that electrostatic interactions can enhance their transport, uptake and retention rather than hindering them. Our lab engineers targeted bioelectrical therapeutics for treatment of diseases affecting such intrinsically charged tissues. We strive to combine basic science with translational research to develop biomedical technologies for unmet clinical needs.
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Our Lab News
Congrats to Tanvi and Tim on their Prize Posters at the College of Engineering Expo! ๐
Tanvi and Tim won the prize for poster categories at the College of Engineering Expo. Congrats!
Read our new work in Osteoarthritis and Cartilage! ๐
Our recently published article explores the use of combining IL-1Ra with cationic drug delivery carriers for post-traumatic osteoarthritis. The work demonstrates that electrically charged IL-1Ra is more effective than neutral IL-1Ra in repairing cartilage. It...
We had a great time at the 2023 Orthopaedic Research Society Annual Meeting in Dallas, TX! ๐
We presented some of our works at 2023 Orthopaedic Research Society Annual Meeting in Dallas, TX: Bioelectricity in Medicine Drug Delivery using Charged Biomaterials - Ambika (Spotlight Talk) Cationic Peptide Modified Exosomes for Cartilage Targeting for Applications...