Molecular Bioelectrostatics & Drug Delivery Laboratory
Located at Northeastern University’s Interdisciplinary Science and Engineering Complex (ISEC), the Bajpayee Lab works at the intersection of biomaterials design, nanomedicine and translational research. We utilize the body’s internal electric fields to design electrically charged biomaterials using proteins, peptides and cellular materials like exosomes, for targeting difficult to reach tissues for applications in drug delivery and diagnostic imaging.
Negatively charged tissues such as cartilage, meniscus, intervertebral disc, eye, and mucosal membrane, that also tend to be dense and avascular, are ubiquitous in the human body but remain outstanding challenges for targeted drug delivery. Their degeneration is associated with several common diseases that remain untreatable due to a lack of delivery systems that can enable drugs to penetrate the negatively charged matrix and reach their cellular targets. The high negative fixed charge density, however, can be converted from being a challenge to an opportunity by engineering therapeutics at the molecular level to add optimally positively charged domains such that electrostatic interactions can enhance their transport, uptake and retention rather than hindering them. Our lab engineers targeted bioelectrical therapeutics for treatment of diseases affecting such intrinsically charged tissues. We strive to combine basic science with translational research to develop biomedical technologies for unmet clinical needs.
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Our Lab News
Our work on cartilage-targeting cationic exosomes was featured in Osteoarthritis and Cartilage Editorial!
Our recently published paper, which was spearheaded by Dr. Tanvi Pathrikar, was highlighted by Dr. Chris Evans on the latest Osteoarthritis and Cartilage (OAC) editorial. In this work, we introduced cationic exosome as a promising non-viral carrier for OA therapeutic...
Check out our research at the 2025 Society For Biomaterials Annual Meeting & Exposition in Chicago, IL!
Bill and Andrew will share our exciting works on charge-based drug delivery for Osteoarthritis treatment. Please stop by our talk annd poster!
Congrats to Tanvi Pathrikar and Coauthors on the recently published work on cartilage-targeting exosomes for OA therapy in Osteoarthritis and Cartilage
In this work led by Dr. Tanvi Pathrikar, we engineered naturally secreted exosomes by reversing their surface charge to enable cartilage-targeting properties via electrostatic interactions. This drug delivery system enabled a...