Molecular Bioelectrostatics & Drug Delivery Laboratory
Located at Northeastern University’s Interdisciplinary Science and Engineering Complex (ISEC), the Bajpayee Lab works at the intersection of biomaterials design, nanomedicine and translational research. We utilize the body’s internal electric fields to design electrically charged biomaterials using proteins, peptides and cellular materials like exosomes, for targeting difficult to reach tissues for applications in drug delivery and diagnostic imaging.
Negatively charged tissues such as cartilage, meniscus, intervertebral disc, eye, and mucosal membrane, that also tend to be dense and avascular, are ubiquitous in the human body but remain outstanding challenges for targeted drug delivery. Their degeneration is associated with several common diseases that remain untreatable due to a lack of delivery systems that can enable drugs to penetrate the negatively charged matrix and reach their cellular targets. The high negative fixed charge density, however, can be converted from being a challenge to an opportunity by engineering therapeutics at the molecular level to add optimally positively charged domains such that electrostatic interactions can enhance their transport, uptake and retention rather than hindering them. Our lab engineers targeted bioelectrical therapeutics for treatment of diseases affecting such intrinsically charged tissues. We strive to combine basic science with translational research to develop biomedical technologies for unmet clinical needs.
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Our Lab News
Frequency Therapeutics Co-op (and fellow Bajpayee Lab researcher!) Matthew Warren working towards the development of a regenerative therapeutic to treat hearing loss
Our undergraduate researcher, Matt Warren, was featured in Boston Globe for his work during Co-op in Frequency Therapeutics. You can read the news [HERE]
Prof. Bajpayee leads a seminar for National Engineers Week 2020!
Dr. Bajpayee presents on her work in engineering a long-lasting pill hosted by the Bioengineering Department.Time: Wednesday February 19; 12:00 PMLocation: 333 Student Curry Center
Congrats Tengfei, Chenzhen and Armin for publishing their paper in Journal of Controlled Release!
Congratulations to Tengfei, Chenzhen, and Armin on our latest publication in Journal of Controlled Release! This is our newest work on mult-arm avidin (mAv) that utilized charge interaction for high rapid intra-cartilage uptake and long retention. We showed that mAv...