In this work, we investigated the contribution of charge and hydrophobicity spatial arrangement on cationic peptide’s intra-cartilage transport. We found that there is an optimum cationic peptide carrier’s residue configuration for cartilage targeting properties. These culminate in simple design rules for the rational design of a charge-based drug delivery system. The paper is online now, and you can check it [HERE]
Congrats to Bill and Coauthors on the recently published work in Biophysical Journal: “Spatial charge-hydrophobicity configuration modulates cationic peptide transport in cartilage”
