by BajpayeeLab | Oct 31, 2025 | Publication
In this work led by Hengli Zhang, we demonstrate that Neosaxitoxin (NSTX) is a potent analgesic for osteoarthritis (OA) associated pain but is limited by rapid joint clearance and short therapeutic duration when delivered as a free drug. Encapsulation within...
by BajpayeeLab | Oct 6, 2025 | Publication
In this work, we investigated the contribution of charge and hydrophobicity spatial arrangement on cationic peptide’s intra-cartilage transport. We found that there is an optimum cationic peptide carrier’s residue configuration for cartilage targeting...
by BajpayeeLab | Apr 21, 2025 | Publication
In collaboration with Dr. Ryan Porter at UAMS, Timothy Boyer and Co-Authors evaluated the kinetics, stability, and immunogenicity of Cationic Peptide Carriers (CPCs) after a single intra-articular injection using a rabbit knee injury model. Our key findings: CPCs...
by BajpayeeLab | Apr 15, 2025 | Publication
Our recently published paper, which was spearheaded by Dr. Tanvi Pathrikar, was highlighted by Dr. Chris Evans on the latest Osteoarthritis and Cartilage (OAC) editorial. In this work, we introduced cationic exosome as a promising non-viral carrier for OA therapeutic...
by BajpayeeLab | Mar 31, 2025 | Publication
In this work led by Dr. Tanvi Pathrikar, we engineered naturally secreted exosomes by reversing their surface charge to enable cartilage-targeting properties via electrostatic interactions. This drug delivery system enabled a sustained interleukin-1 receptor...
by BajpayeeLab | Oct 8, 2024 | Publication
We highlight the promise exosomes have as a next-generation therapy for OA and recent advances in engineering exosomes to enhance their targeted therapeutic potential. The paper is published in Nanoscale and can be accessed [HERE]!
