Congratulations to Helena Mary Baby and co-authors on their new paper in Acta Biomaterialia! Helena engineered positively charged PLGA microparticles that anchor within the nucleus pulposus via electrostatic interactions, providing month-long localized release of a RhoA activator (CN03) that restores cytoskeletal organization in inflamed NP cells. The work demonstrates that tissue electrostatics can be leveraged for spatially confined, sustained delivery in the intervertebral disc — opening new possibilities for disease-modifying therapies in chronic low back pain. You can read the paper [HERE]!